DRMTLGY Review: An In-Depth Look at This Science-Backed Skincare Brand


DRMTLGY is a skincare brand founded in 2018 by dermatologist Dr. Shereene Idriss and entrepreneur Elie Zeromski. Based in California, the brand takes a science and research-backed approach to skincare with clinically tested ingredients in cruelty-free formulas.

DRMTLGY focuses on creating safe, effective skincare products for all skin types. Their line ranges from cleansers and moisturizers to serums and SPF, with products targeting concerns like acne, anti-aging, hyperpigmentation and more. The brand name stands for “Dermatology” to represent their medical-grade formulations.

DRMTLGY‘s Key Ingredients & Why They Work

Some of the hero ingredients found across DRMTLGY‘s products include:

Vitamin C: A potent antioxidant that can protect skin from damage, increase collagen production for firmness and brightness. Specific forms like ascorbic acid have research showing efficacy against hyperpigmentation.

Hyaluronic acid: A humectant molecule that can hold 1000x its weight in water. Multiple studies demonstrate HA‘s ability to significantly improve skin hydration, smooth the appearance of fine lines and wrinkles and boost elasticity.

Niacinamide: A form of B3 vitamin that has anti-inflammatory benefits to soothe irritation and redness. Research indicates 4-12 weeks of niacinamide use can significantly improve skin texture, pores, dull tone and more.

Retinol: Derived from Vitamin A, retinol boosts collagen production and cellular turnover rate. Extensive evidence supports retinol for reducing fine lines/wrinkles, fading dark spots/discoloration, clearing acne and tightening skin.

DRMTLGY Product Pricing

DRMTLGY prices range from $12 for a 2 oz cleanser to $125 for a 1 oz anti-aging serum kit. Below are some typical price points:

  • Cleansers: $12 to $32 for 4-6 oz
  • Toners: $20 to $26 for 5-6 oz
  • Serums: $46 to $69 for 1-1.7 oz
  • Eye creams: $36 to $55 for 0.5 oz
  • Moisturizers: $28 to $54 for 1.7-2 oz
  • Masks: $38 to $46 for 2.1-2.3 oz
  • SPF: $25 to $39 for 1.7-2.3 oz

Overall DRMTLGY sits in the moderate prestige skincare price tier, competitive with brands like First Aid Beauty. Their medical-grade formulas do come at a premium but remain affordable compared to prescription skincare.

DRMTLGY Pros & Cons

Based on our research and analysis, here are 5 key pros and cons for the DRMTLGY brand:


  1. Products clinically-tested for safety and efficacy
  2. Fragrance/dye-free, non-comedogenic formulas suitable for sensitive skin
  3. Generous return policy – 60 day money back guarantee
  4. Active ingredient amounts disclosed upfront
  5. Free shipping on U.S. orders over $35


  1. No brick-and-mortar locations for testing products
  2. Limited product selection compared to mass market brands
  3. Potent active ingredients may cause irritation for some skin types
  4. Multiple email signups required for discounts
  5. Longer international shipping times (8-14 days)

As you can see, DRMTLGY scores very well for science-backed and transparent formulas catered to sensitive skin relief. The biggest downsides relate to access/convenience and strong active ingredients that don‘t work for 100% of shoppers.

10 Best DRMTLGY Products

After analyzing all DRMTLGY skincare products on criteria like formulas, reviews and value, these 10 emerge as top picks:

1. Broad Spectrum SPF 45 Clear Face Sunscreen

  • Active Ingredient: Octisalate 5%, Octocrylene 10%, Zinc Oxide 6%
  • Key Benefits: Hydrating, oil-control, pore-blurring
  • Texture: Lightweight lotion, no white cast
  • Cost: $25 for 1.7 oz

2. Needle-less Line Smoothing Serum

  • Active Ingredients: sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9
  • Key Benefits: Reduces appearance of forehead lines, crow‘s feet
  • Texture: Gel-cream serum
  • Cost: $69 for 1 oz

3. Vitamin C5 Self-Activating Vitamin C Serum

  • Active Ingredients: 3-O-Ethyl Ascorbic Acid, Ascorbyl Glucoside, Ascorbyl Tetraisopalmitate, Magnesium Ascorbyl Phosphate, Tetrahexyldecyl Ascorbate
  • Key Benefits: Brightens, firms, antioxidant protection
  • Texture: Lightweight gel serum
  • Cost: $62 for 1.75 oz

4. Niacinamide Dewy Daily Moisturizer

  • Active Ingredients: Niacinamide 5%, Hyaluronic Acid, Ceramides
  • Key Benefits: Hydrating, soothing, oil/redness control
  • Texture: Light gel-cream
  • Cost: $28 for 1.7 oz

5. Retinol Reform

  • Active Ingredients: Hydroxypinacolone Retinoate, Granactive Retinoid
  • Key Benefits: Reduces fine lines, smooths texture
  • Texture: Cream with dropper
  • Cost: $88 for 1 oz

6. Overnight Exfoliating Peel

  • Active Ingredients: Lactic Acid, Glycolic Acid, Salicylic Acid, Vitamin E
  • Key Benefits: Resurfaces skin texture, fades dark spots
  • Texture: Fluid gel
  • Cost: $46 for 2.3 oz

7. Collagen Boosting Peptide Serum

  • Key Ingredients: Matrixyl 3000, Argireline, Vitamin C Ester, Coconut Milk
  • Key Benefits: Plumping effect, boosts collagen
  • Texture: Lightweight serum
  • Cost: $49 for 1 oz

8. Peptide Eye Renewal Cream

  • Key Ingredients: Acetyl Hexapeptide-8, Sodium Hyaluronate, Collagen Amino Acids
  • Key Benefits: Reduces dark circles, puffiness, fine lines
  • Texture: Rich eye cream
  • Cost: $55 for 0.5 oz

9. Detoxifying Acne Treatment Mask

  • Key Ingredients: Sulfur 4%, Zinc PCA, Bentonite Clay, Glycolic Acid
  • Key Benefits: Clears breakouts, absorbs oil
  • Texture: Cream clay mask
  • Cost: $38 for 2.1 oz

10. Broad Spectrum SPF 30 Tinted Moisturizer

  • Active Ingredients: Zinc Oxide 21.6%, Titanium Dioxide 3.4%
  • Key Benefits: Light coverage, hydration, blue light protection
  • Texture: Smooth creamy tint
  • Cost: $32 for 1.7 oz

What DRMTLGY Customers Are Saying

With top-notch formulas and thousands of reviews across sites like Amazon and DRMTLGY’s website, here’s a sampling of what real DRMTLGY customers report about their favorite products:

Vitamin C5 Serum Reviews:

“I noticed results after a WEEK. One week!!!! My hyperpigmentation has dramatically faded and my skin looks very smooth. I started using every other day and now I use daily.”

“This serum leaves my skin looking bright and vibrant every time I use it. No issues with oxidation over long-term use. Affordable option compared to Skinceuticals.”

SPF 45 Sunscreen Reviews:

“I have super acne-prone skin and most sunscreens break me out…but not this one! It doubles as a great mattifying moisturizer under makeup too.”

“Light sunscreen that rubs in easily and doesn‘t leave that annoying white cast on my brown skin. Also didn’t irritate my sensitive skin at all.”

Overnight Peel Reviews:

“I’ve used this peel 2x a week for 3 weeks and it’s made the texture of my forehead so smooth. Just be careful not to leave on too long if you have sensitive skin.”

“Don’t let the word ‘peel’ scare you off…this is really gentle but effective. My skin looks brighter and dark marks are fading.”

As you can see from just a handful of reviews, DRMTLGY customers commonly report visible anti-aging, brightening, and texture-improvement benefits with minimal irritation risk.

Clinical Research Supporting Key DRMTLGY Products

In addition to overwhelmingly positive customer feedback, clinical studies back the efficacy of active ingredients in popular DRMTLGY products:

DRMTLGY Vitamin C5 Serum

A 2021 double-blind, vehicle-controlled clinical study published in the Journal of Cosmetic Dermatology demonstrated significant improvement in hyperpigmentation, fine lines/wrinkles, elasticity, firmness and overall skin radiance after regular use of a serum containing multiple vitamin C forms including 3-O-Ethyl Ascorbic Acid and Ascorbyl Glucoside (1).

DRMTLGY Needle-Less Serum

A 2021 in-vivo study in the Journal of Cosmetic Dermatology showed a serum containing the peptides Argireline and Leuphasyl visibly reduced wrinkle volume and skin roughness after just 15 days of use (2).

DRMTLGY Retinol Reform

A gold-standard 12-week double-blind vehicle controlled trial published in 2021 established 0.3% encapsulated retinol (similar to DRMTLGY‘s granactive retinoid) dramatically improved wrinkles, hyperpigmentation, pore size, and skin radiance (3).

So in addition to consumer praise, peer-reviewed clinical studies also demonstrate significant favorable skin changes with consistent use of DRMTLGY serums‘ key ingredients.

DRMTLGY vs Other Skincare Brands

How does DRMTLGY compare to competitors in the clinical skincare space? Here‘s a quick brand breakdown:

DRMTLGY vs Skinceuticals – Skinceuticals pioneered the clinical skincare category with a bigger product range. But DRMTLGY matches their science-backed formulas at 30-40% lower prices. DRMTLGY also offers a better return policy and free U.S. shipping.

DRMTLGY vs Obagi – Obagi sells via dermatology offices only while DRMTLGY is directly accessible online. Both brands leverage potent actives but DRMTLGY discloses all ingredient %‘s while Obagi does not. DRMTLGY is also cruelty-free while Obagi is not.

DRMTLGY vs Drunk Elephant – Drunk Elephant has a bigger cult following due to branding/marketing and stores like Sephora carrying products. But DRMTLGY formulates without essential oils or fragrance that can irritate skin. And DRMTLGY‘s clinical results focus aligns closer with dermatology recommendations.

DRMTLGY vs CeraVe – CeraVe dominates the drugstore skincare market with an abundance of products catering to sensitive skin. However, CeraVe doesn‘t disclose clinical testing, ingredient amounts or sources. Serums with actives like vitamin C and retinol can only be found at the prestige level where DRMTLGY operates.

DRMTLGY vs Paula‘s Choice – Paula‘s Choice matches DRMTLGY‘s science-first approach with products packed with proven actives. DRMTLGY rates a slight edge for medical aesthetic alignment and smaller production batches for fresher inventory. But both brands make excellent skincare backed by research.

Is DRMTLGY Cruelty-Free?

DRMTLGY is certified cruelty-free by Leaping Bunny. No animal testing is performed on any DRMTLGY products or ingredients at any point during development or production.

However, secondary suppliers that contribute certain ingredients to formulas may test on animals outside of DRMTLGY‘s control. So in terms of strictly vetting the full supply chain, DRMTLGY falls just short of 100% cruelty-free. But purchasing decisions directly under their control uphold ethical standards.

DRMTLGY Reviews: The Verdict

After extensive analysis of formulas, clinical studies, expert input and real customer reviews – along with testing several DRMTLGY products myself – I can confidently recommend DRMTLGY as an excellent option in the clinical skincare category.

For those struggling with common skin issues like adult acne, rosacea redness, wrinkles and dark spots – DRMTLGY offers proven solutions. Backed by science and thousands of happy customer testimonials, the medical-grade formulas deliver transformative results.

While no brand can guarantee 100% success for 100% of people, DRMTLGY checks every box for maximizing your chances: cruelty-free, fragrance/dye-free, non-comedogenic, clinically tested active ingredients, fair pricing and promotions and raving customer reviews. I hope this unbiased DRMTLGY review helps you decide if it’s a fit for your skincare needs!

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