What is a Natural Substitute for Gabapentin?

Gabapentin is a commonly prescribed medication used to treat nerve pain, restless leg syndrome, hot flashes, and certain types of seizures. It works by altering the way nerves send messages to the brain, helping reduce abnormal electrical nerve activity.

While effective, some people may prefer to avoid prescription gabapentin due to side effects or for other reasons. Fortunately, there are several natural options that may provide similar benefits without a prescription.

In this comprehensive guide, we’ll explore natural gabapentin substitutes in depth so you can make an informed decision about managing your nerve health.

Understanding How Gabapentin Works

Before looking at substitutes, it helps to understand how gabapentin works in the body. This medication is in a class of drugs called anticonvulsants. It’s chemically related to the calming neurotransmitter gamma-aminobutyric acid, or GABA.

Gabapentin is thought to work in a few key ways:

  • Increasing GABA activity in the brain
  • Altering calcium channel functioning
  • Modulating voltage-gated calcium channels
  • Reducing substance P (involved in pain signaling)

Through these mechanisms of action, gabapentin appears to dampen excessive nerve excitability and abnormal electrical activity in the nervous system. This provides its anti-seizure, anti-anxiety, and nerve pain relieving effects.

According to a 2021 research review in Pharmaceuticals, gabapentin has become one of the most widely prescribed medications for neuropathic pain. It’s frequently used for conditions like:

  • Diabetic neuropathy
  • Fibromyalgia
  • Migraines
  • Multiple sclerosis
  • Nerve pain after shingles (postherpetic neuralgia)
  • Peripheral neuropathy
  • Spinal cord injury

In 2016, an estimated 64 million gabapentin prescriptions were filled just in the United States alone.

Potential Gabapentin Side Effects

While often effective for treating nerve pain, gabapentin does come with some potential side effects to be aware of:

  • Drowsiness, fatigue
  • Dizziness
  • Uncoordination, difficulty walking
  • Blurred vision, double vision
  • Weight gain
  • Swelling in hands and feet
  • Dry mouth
  • Headache
  • Tremors
  • Muscle aches

More serious side effects may include:

  • Depression, mood changes
  • Suicidal thoughts
  • Kidney problems
  • Respiratory depression
  • Severe allergic reaction (anaphylaxis)

Gabapentin also carries risks of misuse, dependency, and withdrawal symptoms when stopped suddenly after long-term use. For these reasons, some people prefer to use natural options instead.

Why Consider a Natural Substitute?

There are a few key reasons why someone may want to substitute natural options for gabapentin:

  • Reduce medication side effects – Herbal and nutritional approaches often have fewer side effects compared to gabapentin.

  • Prevent dependency – Natural options have lower addiction potential. This makes them safer for long-term use.

  • Manage milder nerve pain – Mild to moderate neuropathic pain may respond well to natural alternatives, reducing the need for prescription treatment.

  • Complement prescription therapy – Some combine natural options with lower gabapentin doses for a synergistic effect.

  • Personal preference – Many people simply prefer natural remedies over prescription medications when possible.

Of course, natural substitutes may not be right for everyone. Those with severe nerve pain or serious medical conditions may still require gabapentin or other prescription medications for proper management.

Always talk to your healthcare provider before making any changes to your treatment plan. But for those seeking an alternative to gabapentin, let’s explore some options that may help.

Overview of Natural Gabapentin Alternatives

Certain vitamins, minerals, herbs, and supplements appear to provide pain-relieving and nerve-calming effects similar to gabapentin.

While not as potent, these natural alternatives work through some of the same mechanisms, such as modulating GABA activity and calcium channels.

Natural options to consider include:

Vitamins & Minerals:

  • Magnesium
  • Vitamin B12
  • Vitamin D
  • Alpha lipoic acid


  • Valerian root
  • St. John’s wort
  • Kava kava
  • Jamaican dogwood


  • 5-HTP
  • Omega-3 fatty acids
  • Curcumin
  • CoQ10
  • Acetyl-L-carnitine


  • Probiotics
  • Medical cannabis
  • Therapeutic massage

Let’s take a closer look at the evidence behind some of the most promising substitutes.

Magnesium for Nerve Health

Magnesium is an essential dietary mineral involved in over 300 processes in the body. It plays a particularly important role in nerve signaling and neuromuscular function.

Unfortunately, magnesium deficiency is common. According to research, up to 68% of adults don’t get the recommended daily amount of magnesium from food alone.

Chronic deficiency can exacerbate neuropathic pain and nerve dysfunction through effects on pathways like:

  • Calcium channels
  • NMDA receptors involved in pain processing
  • Inflammatory cascades

Correcting deficiency appears to help reduce symptoms of neuropathic pain. For example, a 2015 study in Pain Physician found magnesium supplements decreased pain scores by over 30% in people with neuropathic pain.

Another study found magnesium reduced nerve pain intensity by around 25% in those with painful diabetic neuropathy.

The recommended supplemental dose for nerve pain is typically 300-500 mg elemental magnesium per day. Magnesium glycinate and magnesium threonate are two highly bioavailable forms that cross into the central nervous system effectively.

Magnesium-rich foods like spinach, avocado, almonds, beans, seeds, tofu, and whole grains are also beneficial for getting more magnesium naturally.

5-HTP for Serotonin Support

5-HTP (5-hydroxytryptophan) is a natural compound produced in the body from the amino acid tryptophan. It is used to synthesize serotonin, an important neurotransmitter that regulates pain perception.

Research shows that low serotonin levels are common in those with fibromyalgia and other chronic pain conditions. This contributes to increased sensitization and perception of pain signals.

5-HTP supplements help restore normal serotonin function in the brain and central nervous system. This provides a pain-relieving effect.

According to the International Journal of Tryptophan Research, 5-HTP has demonstrated efficacy comparable to certain antidepressant medications for fibromyalgia. Doses of 50-100 mg up to 3 times per day are typically used.

5-HTP may also improve symptoms of restless legs syndrome, headaches, anxiety, and sleep disturbances – conditions that gabapentin is also used to treat.

However, 5-HTP can cause side effects like nausea and should not be combined with antidepressants without medical supervision. Those with liver or kidney disease should avoid 5-HTP.

The Benefits of Omega-3s

Omega-3 fatty acids like EPA and DHA found in fish oil possess strong anti-inflammatory and pain-relieving properties.

Chronic inflammation appears to play a role in certain types of neuropathic pain. Providing the body with omega-3s may help counter inflammatory processes.

According to a 2020 literature review in Nutrition Reviews:

  • High dose omega-3s decreased pain by 20-50% in studies of chronic back pain and rheumatoid arthritis

  • Omega-3s improved pain and mobility in those with osteoarthritis

  • Reduction in triglyceride levels with omega-3s correlated with less pain

Supplementing with 2-3 grams of fish oil providing at least 1 gram combined EPA/DHA per day is generally recommended for pain conditions. You can also increase omega-3 intake by consuming cold water fatty fish like salmon and mackerel 2-3 times per week.

Omega-3s appear most beneficial for inflammatory types of nerve pain but can complement other natural approaches as part of a comprehensive pain management plan.

Curcumin for Soothing Nerve Discomfort

Curcumin is the active compound found in the bright yellow spice turmeric. It has remarkable antioxidant, anti-inflammatory, and pain-relieving properties.

According to a 2021 literature review in Neural Regeneration Research, curcumin may benefit these conditions:

  • Arthritis
  • Diabetic neuropathy
  • Fibromyalgia
  • Irritable bowel syndrome
  • Migraines
  • Multiple sclerosis

The review authors note that curcumin works through mechanisms like suppressing inflammatory cytokines, inhibiting COX enzymes, and reducing oxidative stress throughout the body – all of which can contribute to neuropathic pain.

Look for a turmeric or curcumin extract standardized to contain 95% curcuminoids for maximum anti-inflammatory activity. The suggested dosage for pain relief is typically 500-1000 mg up to 3 times per day.

Curcumin has an excellent safety profile, even at higher doses. Combining curcumin with piperine (black pepper extract) enhances absorption. Those on blood thinners should consult a healthcare provider before using high-dose curcumin.

Valerian Root for Soothing Anxiety

The herb valerian has a long history of use for relieving anxiety, soothing frayed nerves, and promoting calmness. Much like gabapentin, it appears to work by enhancing GABA activity.

Research shows valerian increases output of GABA in the brain and prevents GABA breakdown, leading to lower anxiety levels. Other studies demonstrate valerian can improve sleep quality.

One clinical trial found valerian worked as well as the anti-anxiety medication oxazepam with fewer side effects. Another study saw reduced neuropathic pain with a combination of valerian and St. John’s wort.

The recommended dosage of valerian root extract standardized to at least 0.5% valerenic acid is 150-450 mg up to 3 times per day. Valerian is considered safe but can cause side effects like headache, dizziness, and upset stomach in some people.

Beneficial Vitamins for Nerve Health

Certain B vitamins and vitamin D also play important roles in healthy nerve functioning and pain regulation. Deficiencies are relatively common, especially vitamin D and vitamin B12.

Correcting deficiencies in these key nutrients may provide additional pain-relieving effects:

  • Vitamin D helps regulate inflammatory processes, endorphin production, and neuromuscular functioning. Those with chronic pain often have low vitamin D levels. Supplementing with 2000-4000 IU per day may offer some pain relief.

  • Vitamin B12 is needed for proper nerve myelin formation and neurotransmitter synthesis. Taking 500-1000 mcg per day corrected deficiencies and reduced nerve pain in clinical studies.

  • Alpha lipoic acid is a potent antioxidant that appears to help reduce neuropathic pain from diabetes. Doses of 600-1200 mg daily are often used.

Discuss supplementation with your doctor to determine if you could benefit from correcting any nutritional deficiencies.

Additional Natural Support for Nerve Health

A few other complementary remedies to consider that may help soothe damaged nerves and provide comfort include:

  • Probiotics: Beneficial gut bacteria can reduce inflammation and balance the nervous system. Look for broad-spectrum probiotic supplements and consume probiotic-rich foods like yogurt, kefir, kimchi, and kombucha.

  • Medical cannabis: In locations where medical cannabis is legal, certain strains and CBD products may help alleviate nerve pain and discomfort. However, long term risks are not fully known. Use cautiously under medical supervision.

  • Therapeutic massage: Gentle massage stimulates pressure receptors that block pain signals to the brain. Massage also improves circulation and reduces painful muscle tightness.

  • Mind-body therapies: Therapies like cognitive behavioral therapy (CBT), meditation, biofeedback, and hypnotherapy help patients better cope with chronic neuropathic pain. Improving pain acceptance and tolerance is key.

Some small studies also report potential benefits from supplements like CoQ10, acetyl-L-carnitine, and topical capsaicin cream containing compounds from chili peppers. These may complement a natural pain relief regimen.

Lifestyle Approaches to Reduce Nerve Discomfort

Certain lifestyle measures and daily habits can also make a big difference in managing neuropathic pain alongside natural alternatives:

  • Exercise: Low-impact activities like walking, swimming, or gentle yoga improve circulation and flexibility which can help reduce nerve pain. But avoid overexertion which can worsen pain.

  • Healthy diet: Limit inflammatory foods like refined carbs, fried foods, alcohol, and added sugars. Focus on antioxidant-rich fruits, vegetables, whole grains, beans, nuts, seeds, and omega-3 rich fatty fish.

  • Stay hydrated: Drink plenty of fluids daily. Dehydration exacerbates nerve discomfort.

  • Good sleep habits: Try to get 7-9 hours per night and keep a consistent sleep schedule. Limit screen time before bed.

  • Stress management: Chronic stress makes pain feel worse. Try relaxation techniques like deep breathing, meditation, nature sounds, or calming music.

  • Alternative therapies: Options like acupuncture, tai chi, qigong massage, or flotation therapy may assist with pain management for some people.

Are Natural Alternatives Right for You?

For those with mild to moderate neuropathic pain or seeking to avoid prescription gabapentin, the natural options explored here appear promising to help manage discomfort.

However, those with severe nerve pain or certain conditions like uncontrolled seizures generally still require gabapentin or other prescription medications, rather than just natural alternatives on their own.

Every person and situation is unique. You may benefit from a combined approach using both prescription and natural pain relievers together, under medical guidance.

Be sure to consult your doctor before changing any treatment plan to ensure your condition remains properly managed. Never discontinue prescription medications without direct medical supervision.

While powerful, gabapentin is not without drawbacks for some people. For those able to incorporate natural substitutes into their pain management routine, the alternatives here provide options to help soothe damaged nerves.

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